Bio inspired accommodating fluid intraocular lens


A corneal or scleral incision allows access to the eye and the smaller the incision the less damage will be done and the less time will be needed for the incision to heal.In addition, the intraocular lens is preferably not damaged during delivery, or at most, minimally damaged such that it will not effect the functionality of the intraocular lens. et al., “Polymer refilling of presbyopic human lenses in vitro restores the ability to undergo accommodative changes,” Invest Ophthalmol Vis Sci, 44(1): 250-257, 2003. et al., “Accommodating intraocular lenses: a critical review of present and future concepts,” Graefe's Arch Clin Exp Ophthalmol, 23-489, 2007. et al., “Accommodation amplitude after lens refilling with injectable silicone by sealing the capsule with a plug in primates,” Arch Ophthalmol, 158-61,1998. et al., “Amplitudes of accommodation of primate lenses refilled with two types of inflatable endocapsular balloons,” Arch Ophthalmol, 177-1684, 1993. et al., “Lens refilling to restore accommodation,” J Cataract Refract Surg, 4-382, 2009. et al, “Synchrony dual-optic accommodating intraocular lens. et al., “Stiffness gradient in the crystalline lens,” Graefe's Arch Clin Exp Ophthalmol, 257-66, 2007. el al., “Subjective and objective performance of the Lenstec KH-3500 “accommodative” intraocular lens,” Br J Ophthalmol, 3-696, 2006. et al., “Visual function after monocular implantation of apodized diffractive multifocal or single-piece monofocal intraocular lens: Randomized prospective comparison,” J Cataract Refract Surg, 36(9):282-285, 2010. This makes the capsule hazy and creates visual disturbances. Surgical Complications The most common surgical complication of lens replacement is posterior capsular opacification (PCO), which occurs when residual lens epithelial cells move to the posterior portion of the capsule and proliferate.

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Delivery devices have been developed to aid in the delivery and insertion of such implants into the eye.All publications and patent applications mentioned in this specification are herein incorporated by reference to the same extent as if each individual publication or patent application was specifically and individually indicated to be incorporated by reference. It may also be important to provide silicone oil that does not reduce the response time of the accommodating IOL.Intraocular lenses (“IOL”) may comprise one or more fluids disposed therein. Some IOLs rely on, or can benefit from, a substantially uniform refractive index throughout the IOL.Systems, devices, and methods are presented for a prosthetic injectable intraocular lens. et al., “Feasibility and development of a high-power real accommodating intraocular lens,” J Cataract Refract Surg, 02-08, 2005. et al., “Numerical modeling of the accommodating lens,” Vision Research, 35-51, 2002. et al., “A self-stabilizing lens ring for 25-gauge vitrectomy surgery,” Am J Ophthalmol, 10-351, 2007. et al., “One-year outcomes with new-generation multifocal intraocular lenses,” Ophthalmology, 108-16, 2008. et al., “Clinical evaluation of the Crystalens AT-45 accommodating intraocular lens: Results of the U. Food and Drug Administration clinical trial,” J Cataract Refract Surg, 2-825, 2006. et al., “MRI study of the changes in crystalline lens shape with accommodation and aging in humans,” J Vis, 11(3):19, 1-16, 2011. et al., “Accommodative lens refilling in rhesus monkeys,” Invest Ophthalmol Vis Sci, 76-2984, 2006. Part 2: Pilot clinical evaluation,” J Cataract Refract Surg, -52, 2007. This application is a continuation-in-part application of U. PCO is treated by externally using a neodymium-doped yttrium aluminium garnet (Nd: YAG) laser to remove a section of the posterior capsule.The lenses can be made from silicone, fluorosilicone, and phenyl substituted silicone and be semipermeable to air. Duane, A., “Normal values of the accommodation at all ages,” JAMA, 59(12):1020-13, 1912. et al., “Change in shape of the aging human crystalline lens with accommodation,” Vision Res, 7-132, 2005. et al., “Meta-analysis of accommodating intraocular lenses,” J Cataract Refract Surg, 2-527, 2007. et al., “Presbyopia and the optical changes in the human crystalline lens with age,” Vision Research, 38(2):209-229, 1998. Kessler, J., “Experiments in refilling the lens,” Arch Ophthalmol, 2-417, 1964. et al., “Accommodation and presbyopia in the human eye—aging of the anterior segment,” Vision Research, 29(12):1685-92, 1989. Pau, H., et al., “The increasing sclerosis of the human lens with age and its relevance to accommodation and presbyopia,” Graefe's Arch Clin Exp Ophthalmol, 24-296, 1990. et al., “Bio-inspired accommodating fluidic intraocular lens,” Opt Lett, 34(20):3214-16, 2009. et al., “Crystalline lens radii of curvature from Purkinje and Scheimpflug imaging,” J Vis, 57-67, 2006. et al., “Age-related changes in human ciliary muscle and lens: Magnetic resonance imaging study,” Invest Ophthalmol Vis Sci, 62-69, 1999. et al., “The mechanism of presbyopia,” Progress in Retinal and Eye Research, 9-393, 2005. Mechanism of Accommodation,” Helmholtz's Treatise on Physiological Optics, pp. It may also be alleviated by cutting the posterior lens capsule with a femtosecond laser.providing an intraocular lens with a flowable media therein within a loading chamber and adjacent a delivery device, wherein the loading chamber and the delivery device are in fluid communication, the intraocular lens including an optic portion, a distal haptic, and a proximal haptic; and wherein loading the intraocular lens into the delivery device comprises compressing an optic portion of the intraocular lens from an unstressed expanded configuration to a stressed delivery configuration.

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